A GP practice and walk-in centre is to open in a Boots store in Manchester city centre.
The surgery is the first of its kind to open in the North West and has the capacity to register 8,500 patients.
The surgery, which will open late this year on Cross Street, will be run by not-for-profit organisation GTD Primary Care, for NHS patients.
Patients will be able to access the surgery either through the store itself or directly from Cross Street 365 days a year, from 8am to 8pm.
The new service will increase the number of GPs working in the city centre and enable more residents living in the city to register with a local surgery, as well as offering appointments for unregistered patients.
Laura Roberts, Chief Executive of NHS Manchester, said: "We need to make more GP appointments available in the city centre area and the new service will enable us to do that. The choice of location should make it easy for people to access and we're pleased to be leading such an innovative partnership."